Andrew Johnston House is a historic home located at Pearisburg, Giles County, Virginia. The central block was built in 1829, and is a two-story, five bay, central-passage plan, brick house over a low basement in the Federal style. It features a one-story, flat-roofed front portico topped by a balustrade and supported by two Ionic order and two Tuscan order columns. Also on the property is a small contributing outbuilding that was built as a doctor's office about 1857. The building houses the Giles County Historical Society, which uses it as a museum and research center.It was listed on the National Register of Historic Places in 1993.
