Athens B & O Train Depot is a historic railroad building in Athens, Ohio. It was listed in the National Register of Historic Places on January 11, 1983. The path of the B&O Railroad tracks went past this site, before they were removed and the tracks area made a car park.This building is currently under lease to a private concern.The station was used by Amtrak's Shenandoah, operating between 1976 and 1981.