Cape Girardeau County is a county located in the southeastern part of the U.S. state of Missouri; its eastern border is formed by the Mississippi River. As of the 2010 U.S. Census, the population was 75,674. The county seat is Jackson, the first city in the US to be named in honor of President Andrew Jackson. Officially organized on October 1, 1812, the county is named after Ensign Sieur Jean Baptiste de Giradot, an official of the French colonial years. The "cape" in the county's name is named after a former promontory rock overlooking the Mississippi River; this feature was demolished during railroad construction.Cape Girardeau County is the central hub of the Cape Girardeau - Jackson, MO-IL Metropolitan Statistical Area. Its largest city is Cape Girardeau.HistoryCape Girardeau County was organized on October 1, 1812, as one of five original counties in the Missouri Territory after the US made the Louisiana Purchase of 1803. It is named after Ensign Sieur Jean Baptiste de Girardot (also spelled Girardeau or Girardat), a French officer stationed 1704–1720 at Kaskaskia in what the French called the Illinois Country. In 1733 he founded a trading post on the Mississippi River, which developed as the present-day city of Cape Girardeau. The "cape" in the county name was a rock promontory overlooking the Mississippi River and Claire's house; the original cape rock was destroyed by railroad construction.