Charleston County is a county located in the U.S. state of South Carolina along the Atlantic coast. As of the 2010 census, its population was 350,209, making it the third most populous county in South Carolina (behind Greenville and Richland counties). Its county seat is Charleston. The county was created in 1901 by an act of the South Carolina State Legislature.Charleston County is included in the Charleston-North Charleston, SC Metropolitan Statistical Area.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (33%) is water. It is the largest county in South Carolina by total land and water area.Adjacent countiesBerkeley County - northGeorgetown County - northeastColleton County - westDorchester County - northwestNational protected areas Cape Romain National Wildlife Refuge Charles Pinckney National Historic Site Ernest F. Hollings ACE Basin National Wildlife Refuge (part) Fort Moultrie National Monument Fort Sumter National Monument Francis Marion National Forest (part)