Comanche County is a county located in the U.S. state of Oklahoma. As of the 2010 census, the population was 124,098, making it the fourth-most populous county in Oklahoma. Its county seat is Lawton. The county was created in 1901 as part of Oklahoma Territory. It was named for the Comanche tribe.Comanche County is included in the Lawton, OK Metropolitan Statistical Area.Built on former reservation lands of the Comanche, Kiowa, and Apache in Indian Territory, Comanche County was open for settlement on August 16, 1901 by lottery. The region has three cities and seven towns as well as the Fort Sill military installation and Wichita Mountains Wildlife Refuge. The landscape of the county is typical of the Great Plains with flat topography and gently rolling hills, while the areas in the north are marked by the Wichita Mountains. Interstate 44 and three major US Highways serve the county by ground, while the Lawton-Fort Sill Regional Airport serves the county by air.