Florence is a Statutory City located in Fremont County, Colorado, United States. The population was 3,881 at the 2010 census, up from 3,653 in 2000.HistoryFlorence was built as a transportation center, with three railroads including a small railroad depot for the trains that hauled coal from the neighboring towns of Rockvale and Coal Creek. Oil was first discovered in Florence in 1862, being the first oil center west of the Mississippi. In the early 1880s the town grew rapidly. The city was named after Florence, the daughter of local settler James McCandless. The town was incorporated in 1887.GeographyFlorence is in eastern Fremont County, on the south side of the Arkansas River. It is bordered to the west by the town of Williamsburg, and the town of Coal Creek is 3mi to the southwest. Colorado State Highway 115 runs northwest 9mi to Cañon City and northeast 6mi to Penrose, intersecting U.S. Route 50 in each direction. Colorado State Highway 67 leads north to US 50 and south to Wetmore. Pueblo is to the east via CO 115 and US 50.