Grenada County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 21,906. Its county seat is Grenada. The county is named for the province of Granada in southern Spain. Its western border is formed by the Yazoo River and it fronts on the Mississippi Delta. Cotton cultivation was important to its economy well into the 20th century.The Grenada, MS Micropolitan Statistical Area includes all of Grenada County.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (6.1%) is water.Major highways20px Interstate 5520px U.S. Highway 5120px Mississippi Highway 7 20px Mississippi Highway 8 20px Mississippi Highway 35