Gruene is a former town in Comal County in the U.S. state of Texas. Once a significant cotton-producing community along the Guadalupe River, the town has now shifted its economy to one supported primarily by tourism. Gruene is now a district within the city limits of New Braunfels, and much of it was listed in the National Register of Historic Places on April 21, 1975. It is part of the San Antonio-New Braunfels Metropolitan Area.
