Hoxie is a town in Lawrence County, Arkansas, United States. It lies immediately south of Walnut Ridge. The population was 2,780 at the 2010 census.GeographyHoxie is located at .According to the United States Census Bureau, the city has a total area of 4.0sqmi, all land.List of highways25px U.S. 63 Business25px U.S. 67 Business U.S. Highways 63 and 67 intersect and cross each other in Hoxie. U.S. 63 enters Arkansas at the Missouri line at Thayer, Missouri, and Mammoth Spring, Arkansas, two contiguous cities. U.S. 63 then goes southeastward to connect with Interstate 55 near Turrell, in Crittenden County. It runs contiguous with I-55 and I-40 for a ways. Both those interstates cross the Mississippi River into Memphis, Tennessee. U.S. 63 is then contiguous with a number of other routes southward in Arkansas, leaving Arkansas for Louisiana at Junction City, in Union County. U.S. 67 is a southwest—northeast bisector of Arkansas.