Isanti County is a county located in the U.S. state of Minnesota. As of the 2010 census, the population was 37,816. Its county seat is Cambridge. Isanti is derived from the Dakota word meaning "knife" and refers to the Santee tribe.Isanti County is included in the Minneapolis-St. Paul-Bloomington, MN Metropolitan Statistical Area.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (3.5%) is water.Major highways20px Minnesota State Highway 4720px Minnesota State Highway 6520px Minnesota State Highway 9520px Minnesota State Highway 107List of county roads