Madison County is a county located in the northeastern part of the U.S. state of Georgia. As of the 2010 census, the population was 28,120. The county seat is Danielsville. The county was created on December 5, 1811. The county's largest city is Comer with a population of 1,200.Madison County was included in the Athens-Clarke County, GA Metropolitan Statistical Area, which is included in the Atlanta-Athens-Clarke County-Sandy Springs, GA Combined Statistical Area.HistoryNamed for James Madison, fourth president of United States, from 1809 to 1817, Madison County, was organized under act of General Assembly of Georgia, December 11, 1811. It was the 38th county formed in Georgia and began to operate as a county in 1812. Madison County formed from Oglethorpe, Clarke, Jackson, Franklin and Elbert counties.Early agriculture in Madison County was devoted to food crops and livestock (cattle, hogs and sheep), which was sufficient to feed the population. Just after the Civil War ended, the demand for a cash crop led to a major reliance on cotton. The soils of Madison County were heavily damaged by this cotton monoculture. From the 1930s on, agriculture became more diverse. Today, agribusiness dominates the local economy, with poultry production particularly important.