Mahato Laboratory
Our laboratory has expertise in molecular and cell biology, biochemistry, biophysics, polymer chemistry, colloid science, pharmaceutics, and medicine. This allows us to take a multidisciplinary approach for successful research and training students and post-doctoral fellows. Our research is focused on the following areas: (i) Micelle and Nanoparticulate Drug Delivery, (ii) Oligonucleotides, siRNA, shRNA and Gene Delivery (iii) Synthesis of Novel Polymers, Lipopeptides, Lipopolymers and Cationic Lipids (iv) Construction of Plasmid and Adenovirus-based Gene and shRNA Expression Systems. These systems are being tested in various disease areas such as improving islet transplantation to treat type 1 diabetes, cancer (pancreatic, prostate and breast) and liver fibrosis.
We attempt to understand how the individual components of delivery and expression systems would influence the disease state by controlling gene regulation, transcription, translation and replication. In addition to using stem cells as gene delivery vehicle for inducing immune tolerance in diabetes and fibrosis, we are also working to overcome multi drug resistance in tumors by targeting cancer stem cells.
Key Words: Nanomedicine and Drug Delivery, Gene Medicine, Biomaerials, Human Islet Transplantations, Liver fibrosis, Prostate Cancer, Pancreatic Cancer
Our mission is to train graduate students and post-doctoral fellows in the area of pharmaceutics and drug delivery and nanomedicine.
