The US Post Office—Holyoke Main is a historic post office building at 650 Dwight Street in Holyoke, Massachusetts. It opened in 1935, as a replacement for an earlier post office location at 31 Main Street. The Art Deco building, a stylistic rarity in Holyoke, was built for a total cost (including land and construction) of $284,000. The main construction material was limestone, with granite detailing. Inside it has a mural, painted in the 1930s, depicting the early settlement of Holyoke. The building was listed on the National Register of Historic Places in 1986.
