Wayne County is a county located in the Ozark foothills in the U.S. state of Missouri. As of the 2010 census, the population was 13,521. The county seat is Greenville. The county was officially organized on December 11, 1818, and is named after General "Mad" Anthony Wayne who served in the American Revolutionary War.HistoryWayne County was created in December 1818 by the last Missouri Territorial Legislature from portions of Cape Girardeau and Lawrence counties. Wayne County thus actually predates statehood. In March 1819, Congress established the Territory of Arkansas, and most of Lawrence County became Lawrence County, Arkansas Territory. The small strip that had been excluded was added to Wayne County by the Missouri State Constitution of 1820. The Osage Strip on the Kansas border was added in 1825. Between 1825 and 1831, Wayne County was actually larger than the states of Massachusetts, Connecticut, Rhode Island, and Delaware combined. All or part of 32 present Missouri counties once belonged to Wayne County. Despite its size, the Census of 1820 revealed that Wayne County had a total population of just 1,239 white inhabitants and 204 African American slaves.
