Waynesboro is a city in Wayne County, Mississippi, United States. The population was 5,043 at the 2000 census. It is the county seat of Wayne County.GeographyWaynesboro is located at, just east of the Chickasawhay River.According to the United States Census Bureau, the city has a total area of 6.7sqmi, of which 6.7sqmi is land and 0.15% is water.DemographicsAs of the 2010 United States Census, there were 5,043 people residing in the city. 61.9% were African American, 35.2% White, 0.2% Native American, 0.3% Asian, 0.1% Pacific Islander, 1.4% from some other race and 1.0% of two or more races. 1.9% were Hispanic or Latino of any race.As of the census of 2000, there were 5,197 people, 1,982 households, and 1,335 families residing in the city. The population density was 781.6 people per square mile (301.7/km²). There were 2,276 housing units at an average density of 342.3 per square mile (132.1/km²). The racial makeup of the city was 41.54% White, 57.28% African American, 0.21% Native American, 0.37% Asian, 0.25% from other races, and 0.35% from two or more races. Hispanic or Latino of any race were 0.94% of the population.