Clio is a town in Marlboro County, South Carolina, United States. The population was 774 at the 2000 census. Marlboro School of Discovery is a magnet school in Clio, South Carolina and is part of the Marlboro County School District.HistoryThe Clio Historic District, McLaurin House, and McLaurin-Roper-McColl Farmstead are listed on the National Register of Historic Places.GeographyClio is located at .According to the United States Census Bureau, the town has a total area of 0.8sqmi, all land.DemographicsAs of the census of 2000, there were 774 people, 302 households, and 192 families residing in the town. The population density was 926.4 people per square mile (355.8/km²). There were 339 housing units at an average density of 405.8 per square mile (155.8/km²). The racial makeup of the town was 36.05% White, 57.11% African American, 6.20% Native American, 0.13% from other races, and 0.52% from two or more races. Hispanic or Latino of any race were 0.52% of the population.