Gretna is a city in Gadsden County, Florida, United States. The population was 1,460 as of the 2010 census, down from 1,709 at the 2000 census. It is located on U.S. 90 and is approximately 8mi south of the Florida-Georgia border.Gretna is part of the Tallahassee, Florida Metropolitan Statistical Area.GeographyGretna is located in west-central Gadsden County at . In recent years the city limits have expanded south and west 5mi to encompass part of Interstate 10; the city is now bordered on the south by Greensboro.U.S. Route 90 passes through Gretna as Main Street; it leads southeast 5mi to Quincy, the Gadsden County seat, and northwest to Chattahoochee. Interstate 10 passes through the southwest part of Gretna, with access from Exit 174 . I-10 leads east to Tallahassee and west to Pensacola. SR 12 leads southwest to Bristol, and SR 65 leads south to Hosford.