Manitowoc County is a county in the U.S. state of Wisconsin. As of the 2010 census, the population was 81,442. Its county seat is Manitowoc. The county was created in 1836 prior to Wisconsin's statehood and organized in 1848.Manitowoc County comprises the Manitowoc, WI Micropolitan Statistical Area.GeographyAccording to the U.S. Census Bureau, the county has a total area of, of which is land and (61%) is water.Major highwaysAirportManitowoc County Airport (KMTW) serves the county and surrounding communities.Adjacent countiesBrown County – northwestKewaunee County – northeastSheboygan County – southCalumet County – west