Packwood House-American Hotel, also known as the Packwood House Museum, is a historic inn and tavern located at Lewisburg, Union County, Pennsylvania, USA. It was originally built about 1813, and expanded about 1866. It is a three-story, log and frame building with a gable roof. It has a two-story, pent roof rear addition. It has housed a decorative arts museum since 1972.It was listed on the National Register of Historic Places in 1978. It is located in the Lewisburg Historic District.
