Wheeling Creek is a tributary of the Ohio River, 25 miles (40 km) long, in the Northern Panhandle of West Virginia in the United States, with a watershed extending into southwestern Pennsylvania. Via the Ohio River, it is part of the watershed of the Mississippi River, draining an area of approximately 300sqmi on the unglaciated portion of the Allegheny Plateau. It flows into the Ohio River in downtown Wheeling, just downstream of Ohio's Wheeling Creek on the opposite bank. According to the Geographic Names Information System, it has also been known as Big Wheeling Creek.
