The Caloosahatchee National Wildlife Refuge is part of the United States National Wildlife Refuge System, located on the Caloosahatchee River, beneath the I-75 Caloosahatchee Bridge, within the city of North Fort Myers. The 40acre refuge was established on January 1, 1921. It is administered as part of the J.N. 'Ding' Darling National Wildlife Refuge Complex.
