Philadelphia is a city in and the county seat of Neshoba County, Mississippi, United States.
The region of Neshoba county and the surrounding counties was the heart of the Choctaw Nation from the 17th century until removal of most of the people in the 1830s. European-American settlers began to arrive in numbers in the early decades of the nineteenth century, after French, British and Spanish traders developed business relationships with the Choctaw.