Interstate 65 is a major Interstate Highway in the central United States. As with most interstates that end in a five, it is a major cross-country, north-south route, connecting the Gulf of Mexico to the Great Lakes. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with I-90, U.S. Route 12, and US 20 in Gary, Indiana, just southeast of Chicago.I-65 connects several major metropolitan areas in the Midwest and Southern United States. It connects the four largest cities in Alabama . It also serves as one of the main north-south routes through Nashville, Tennessee, Louisville, Kentucky, and Indianapolis, Indiana, each a major metropolitan area in each respective state.Route description|- | AL | 367.00 | 590.63 |- | TN | 121.71 | 195.87 |- | KY | 137.32 | 221.00 |- | IN | 261.27 | 420.47 |- | Total | 887.30 | 1427.97 |}
